Remez's Procedure for Finding Optimal Designs
نویسندگان
چکیده
منابع مشابه
Optimal designs for dose finding studies
Identifying the “right” dose is one of the most critical and difficult steps in the clinical development process of any medicinal drug. Its importance cannot be understated: selecting too high a dose can result in unacceptable toxicity and associated safety problems, while choosing too low a dose leads to smaller chances of showing sufficient efficacy in confirmatory trials, thus reducing the c...
متن کاملwww.econstor.eu Optimal designs for dose finding studies
Identifying the “right” dose is one of the most critical and difficult steps in the clinical development process of any medicinal drug. Its importance cannot be understated: selecting too high a dose can result in unacceptable toxicity and associated safety problems, while choosing too low a dose leads to smaller chances of showing sufficient efficacy in confirmatory trials, thus reducing the c...
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Optimal design under a cost constraint is considered, with a scalar coefficient setting the compromise between information and cost. It is shown that for suitable cost functions, by increasing the value of the coefficient one can force the support points of an optimal design measure to concentrate around points of minimum cost. An example of adaptive design in a dose-finding problem with a biva...
متن کاملPractical considerations for optimal designs in clinical dose finding studies.
A key objective in the clinical development of a medicinal drug is the determination of an adequate dose level and, more broadly, the characterization of its dose response relationship. If the dose is set too high, safety and tolerability problems are likely to result, while selecting too low a dose makes it difficult to establish adequate efficacy in the confirmatory phase, possibly leading to...
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Particle Swarm Optimization (PSO) is a meta-heuristic algorithm that has been shown to be successful in finding the optimum solution or close to the optimum for a wide variety of real and complicated optimization problems in engineering and computer science. This paper adapts PSO methodology by first solving an optimization problem on the hypercube and then projecting the solution onto the q-si...
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ژورنال
عنوان ژورنال: The Annals of Statistics
سال: 1976
ISSN: 0090-5364
DOI: 10.1214/aos/1176343659